Boseman has battled colon cancer since 2016 and died at home with his family and wife by his side, according to a statement posted on his Twitter account. He was 43.
"A true fighter, Chadwick persevered through it all, and brought you so many of the films you have come to love so much," the statement said.
"From Marshall to Da 5 Bloods, August Wilson's Ma Rainey's Black Bottom and several more, all were filmed during and between countless surgeries and chemotherapy."
With his role as King T'Challa in the boundary-breaking film "Black Panther," he became a global icon and an inspiring symbol of Black power. That role was the "honor of (Boseman's) career," the statement said.
He graduated from Howard University
A South Carolina native, Boseman graduated in 2000 from Howard University, a historically Black college in Washington, DC. While there, he also attended the British American Drama Academy at Oxford in 1998.
"It is with profound sadness that we mourn the loss of alumnus Chadwick Boseman who passed away this evening. His incredible talent will forever be immortalized through his characters and through his own personal journey from student to superhero! Rest in Power, Chadwick!" University President Wayne A. I. Frederick said in a statement.
Boseman's breakout performance came in 2013 when he played Jackie Robinson in the film "42." Boseman's passing was announced the day Major League Baseball honored Jackie Robinson Day, an annual commemoration delayed by several months due to the pandemic.
"His transcendent performance in '42' will stand the test of time and serve as a powerful vehicle to tell Jackie's story to audiences for generations to come," Major League Baseball tweeted Friday about the actor.
Boseman made his Marvel Cinematic Universe debut in 2016 as T'Challa/Black Panther in "Captain America: Civil War. Black Panther then got his own stand-alone movie that released in 2018, which broke box office records. Marvel Studios president had previously announced the second movie of the "Black Panther" saga would debut in theaters in May 2022.
Boseman returned to his alma mater in 2018 to give the commencement speech. He told the graduates about his early days acting on soap operas, saying he was fired from an unnamed production after he questioned what he felt was its stereotypical portrayal of Black characters.
"The struggles along the way are only meant to shape you for your purpose," he said at the time.
He concluded with his iconic "Wakanda Forever" salute.
'A superhero to many'
Boseman "brought history to life" with his roles, Martin Luther King III said.
"As Black Panther, he was also a superhero to many," he wrote on Twitter. "And despite his 4 year long battle with cancer, he kept fighting and he kept inspiring. He will be missed."
The NAACP also paid tribute to the actor, saying Boseman showed "us how to conquer adversity with grace."
"For showing us how to 'Say it Loud!' For (showing) us how to walk as a King, without losing the common touch. For showing us just how powerful we are," their Instagram statement said. "Thank you #ChadwickBoseman."
Sen. Kamala Harris, who also attended Howard, said she was heartbroken over Boseman's death.
"My friend and fellow Bison Chadwick Boseman was brilliant, kind, learned, and humble," she tweeted. "He left too early but his life made a difference. Sending my sincere condolences to his family."
Actor Mark Ruffalo, who starred aside Boseman in the Marvel movies as the Hulk, said the death adds to the growing list of tragedies in 2020.
"What a man, and what an immense talent," Ruffalo tweeted. "Brother, you were one of the all time greats and your greatness was only beginning. Lord love ya. Rest in power, King."