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HIV vaccine trial ends in 'deep disappointment'

A clinical trial for an HIV vaccine has been discontinued since the vaccine was not found to prevent infections of human immunodeficiency virus, the virus th...

Posted: Feb 3, 2020 2:22 PM

A clinical trial for an HIV vaccine has been discontinued since the vaccine was not found to prevent infections of human immunodeficiency virus, the virus that causes AIDS.

The National Institute of Allergy and Infectious Diseases or NIAID, which sponsored the trial, announced on Monday that the study taking place in South Africa was halted after an independent data and safety monitoring board found the vaccine to be ineffective in preventing HIV. NIAID noted that the board did not express any concerns about safety.

"An HIV vaccine is essential to end the global pandemic, and we hoped this vaccine candidate would work. Regrettably, it does not," Dr. Anthony Fauci, director of the NIAID, said in a written statement on Monday.

"Research continues on other approaches to a safe and effective HIV vaccine, which I still believe can be achieved," he said.

In a separate news release, the Global HIV Vaccine Enterprise announced "deep disappointment" that the vaccine study had been stopped. The enterprise is an alliance of funders and stakeholders formed to accelerate the search for an HIV vaccine.

"Whilst this is a significant setback for the field, we need to continue the quest for a preventive vaccine. The rates of HIV infection, which continue unabated in this region, should spur greater urgency, global attention and investment to the quest," Linda-Gail Bekker, immediate past president of the International AIDS Society and chair of the Enterprise Advisory Group, said in that separate announcement.

The vaccine trial, named HVTN 702 or Uhambo, began in 2016 and enrolled 5,407 HIV-negative volunteers at 14 sites across South Africa, according to NIAID. Those volunteers were sexually active men and women ages 18 to 35 who were randomly assigned to receive either the vaccine or placebo injections.

An analysis of the study showed no significant difference in subsequent HIV infections among the volunteers in the vaccine group versus placebo group. According to NIAID, 129 HIV infections occurred among the vaccine recipients and 123 HIV infections occurred among the placebo recipients. NIAID said that those study participants are being informed of the trial stopping and researchers will continue to follow study participants over time.

This trial wasn't the only investigation into approaches to prevent HIV. The National Institutes of Health has invested in two other late-stage, multinational HIV vaccine trails, both testing a novel vaccine regimen, among other HIV prevention trials.

Additionally, the use of a daily pill to prevent HIV infection called PrEP rose almost 500% from 2014 to 2017 in the United States, according to research published in July by the US Centers for Disease Control and Prevention.

In December, US Health and Human Services Secretary Alex Azar announced the launch of a national program to provide free HIV-prevention drugs to uninsured adults in the United States at risk of HIV.

Indiana Coronavirus Cases

Data is updated nightly.

Cases: 1118335

Reported Deaths: 17712
CountyCasesDeaths
Marion1455892240
Lake724831254
Allen67063882
Hamilton51060487
St. Joseph49820649
Elkhart40268546
Vanderburgh34714497
Tippecanoe30808276
Johnson27696467
Hendricks26313385
Porter25657386
Madison21131455
Clark20238279
Vigo19059309
LaPorte17192261
Howard16770314
Delaware16761303
Monroe16628220
Kosciusko14293167
Hancock13113186
Bartholomew12983190
Warrick12210190
Wayne12090269
Floyd12011226
Grant11998245
Morgan10409192
Boone9869124
Noble9316122
Henry9177169
Marshall9152147
Dearborn8970100
Dubois8835140
Shelby8281130
Cass8167128
Lawrence8057185
DeKalb7817109
Jackson770793
Huntington7661115
Gibson7102118
Montgomery7101123
Harrison6954100
Knox6915116
Steuben669089
Whitley659660
Miami6595113
Putnam645085
Clinton627179
Wabash6221111
Jasper613192
Jefferson5856105
Ripley557294
Adams542281
Daviess5076117
Scott491580
Wells4836105
White478469
Greene4701101
Clay464662
Decatur4611110
Fayette452496
Jennings452067
LaGrange427491
Posey410044
Randolph3944107
Washington390956
Fountain375964
Fulton364874
Spencer362247
Starke355574
Owen353577
Sullivan348555
Orange331372
Jay331050
Rush309533
Carroll296239
Franklin292744
Perry290553
Vermillion283658
Tipton251167
Parke250130
Pike248644
Blackford222144
Pulaski210359
Newton182452
Brown177550
Crawford169129
Benton168417
Martin152120
Switzerland147612
Warren135816
Union122616
Ohio92413
Unassigned0595

Ohio Coronavirus Cases

Data is updated nightly.

Cases: 1731003

Reported Deaths: 26851
CountyCasesDeaths
Franklin1803711843
Cuyahoga1698662655
Hamilton1144371544
Montgomery810251405
Summit726231210
Lucas636141027
Butler57225814
Stark543091183
Lorain42754645
Warren36183417
Mahoning36035788
Lake32696501
Clermont31523369
Trumbull27614620
Delaware27394185
Licking26829344
Medina26290353
Fairfield24812287
Greene24540373
Clark22327390
Portage21504283
Richland21257342
Wood20300248
Allen19119326
Miami17456352
Columbiana17014335
Muskingum16873207
Wayne15873307
Tuscarawas14579362
Marion13440196
Ashtabula12927237
Erie12790199
Scioto12556188
Pickaway12308155
Ross11780226
Hancock11623175
Geauga11042179
Lawrence10698172
Belmont10509234
Huron9867159
Jefferson9687228
Union963775
Sandusky9428166
Seneca8993161
Knox8869176
Washington8714159
Darke8435181
Athens841897
Ashland8102152
Auglaize8018120
Shelby7551135
Defiance7418117
Crawford7356150
Fulton7262113
Brown7217116
Logan7061111
Guernsey700586
Mercer6959100
Highland6807120
Clinton6547106
Williams653899
Madison652590
Preble6334140
Putnam6288122
Champaign585187
Jackson584597
Perry570579
Ottawa5689102
Coshocton5688108
Morrow521765
Fayette497272
Hardin4947100
Gallia474278
Van Wert469395
Pike467678
Adams4619110
Henry439280
Hocking412493
Holmes4035141
Wyandot379275
Carroll371178
Paulding326351
Meigs307561
Monroe236861
Noble221549
Morgan219039
Harrison215253
Vinton189138
Unassigned06
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