Authorities have intercepted bombs intended for former President Barack Obama and Hillary Clinton, and several other top political figures were targeted in what authorities are investigating as a connected series of incidents.
Also, CNN's New York bureau in the Time Warner Center was evacuated after a package containing a bomb, addressed to former CIA Director John Brennan, was discovered, city and local law enforcement officials said.
In addition, sources told CNN that a suspicious package intended for California Democratic Rep. Maxine Waters was intercepted at a congressional mail screening facility in Maryland; New York Gov. Andrew Cuomo received what he said was a device at his Manhattan office; and the San Diego Union-Tribune evacuated its building after "suspicious looking packages" were spotted outside.
Later Wednesday night, two law enforcement sources told CNN that law enforcement officials are trying to track down a package addressed to former Vice President Joe Biden now considered suspicious because of similarities to other packages. The package was misaddressed and returned to sender.
The developments, which unfolded rapidly and continued steadily into the afternoon, touched off fear and confusion and immediately invited questions about the motives of those responsible. The recipients of the packages are all prominent targets of right-wing criticism and, in many cases, of President Donald Trump himself.
"This clearly is an act of terror attempting to undermine our free press and leaders of this country through acts of violence," New York Mayor Bill de Blasio said at an afternoon news conference.
CNN, citing a law enforcement official, was initially told a suspicious package containing a pipe bomb that was addressed to the White House was intercepted at Joint Base Bolling in Washington, DC. The Secret Service, however, later said it had only intercepted the two packages intended for Obama and Clinton and called reports of a package headed for the White House "incorrect."
Trump says 'no resources' will be spared
Trump vowed Wednesday afternoon that "the full weight of our government is being deployed to conduct this investigation."
"We will spare no resources or expense in this effort," Trump said at the top of his remarks at a White House opioid bill signing event. He said he had just concluded a briefing with the FBI, Department of Justice, Homeland Security Department and Secret Service.
The President -- who has recently taken to calling his political opponents "evil" -- called for unity in his remarks and said "we have to come together and send one very clear, strong, unmistakable message that threats or acts of political violence have no place in the United States of America."
"This egregious conduct is abhorrent to everything we hold dear and sacred as Americans," Trump said, adding, "We are extremely angry, upset, unhappy about what we witnessed this morning, and we will get to the bottom of it."
His remarks were greeted with a standing ovation in the room.
Devices appear to be similarly constructed
Bryan Paamann, an FBI special agent in charge of the counterterrorism division in New York, said the devices appeared to be pipe bombs. A law enforcement official told CNN that the initial examination of all of the devices shows them to be constructed similarly. At least one of the devices appeared to contain projectiles, including shards of glass. The devices are rudimentary but functional.
A law enforcement source said the device found in the Time Warner Center's mailroom is similar to the ones addressed to Obama, Clinton and billionaire investor and major Democratic donor George Soros, which was discovered earlier this week. The package to Brennan was delivered by courier, law enforcement sources said.
Neither Obama nor Clinton received the packages sent to them or were at risk of receiving them, the Secret Service said. They were discovered during "routine mail screening procedures as potential explosive devices and were appropriately handled as such," the agency said in a statement.
The package intended for Obama was intercepted in Washington, DC, and the one intended for Clinton was addressed to her Chappaqua residence in Westchester County, New York, on Tuesday, authorities said.
Speaking in Florida early Wednesday afternoon to campaign for Democrat Donna Shalala's congressional bid, Clinton said she and her husband, former President Bill Clinton, were "fine" and praised the response by the Secret Service.
A suspicious package sent to the Florida office of Democratic Rep. Debbie Wasserman Schultz was intended for former Attorney General Eric Holder but had the wrong address, two law enforcement sources said. It was returned to the Democratic congresswoman because that was the return label on the package, the sources said, adding that it was the same return address for the packages sent to Obama and Clinton.
On the package sent to Biden and returned to sender, it was not clear if the return address was Wasserman Schultz's or another address. Authorities are trying to locate it, the officials told CNN.
Packages sent to Soros, Clinton, CNN, Obama, Holder and Waters were all sent with Wasserman Schultz's office as the return address in manila envelopes with bubble wrap interior, the FBI said in a statement Wednesday. Each package had six Forever stamps on the envelope as well.
The bombs show the presence of a sulfur substance, which could have exploded. The devices were pipe bombs and are inherently unstable, and could have been set off just by handling.
There is no information that suggests Wasserman Schultz sent the packages. The bomb squad was investigating the package discovered at Wasserman Schultz's office, a local police spokesman said. It was not immediately clear if the package contains a device similar to the others detected around the country.
The Soros package was believed to have been placed in a mailbox rather than mailed, a separate law enforcement source said.
The package addressed to Waters had similarities to the other suspicious packages, according to two law enforcement sources. One source said that belief was based on the timing, packaging and devices inside the packages, though it was not clear if it was capable of exploding.
Later on Wednesday, a spokesperson for the Bureau of Alcohol, Tobacco, Firearms and Explosives, Ginger Colbrun, said a second package addressed to Waters had been found at a postal facility in south central Los Angeles. Colbrun told CNN the package matches the description of those sent to CNN and Democratic political figures. The Los Angeles Police Department said the postal facility was evacuated while an investigation takes place.
FBI Director Christopher Wray said in a statement the investigation is the "highest priority for the FBI."
"We have committed the full strength of the FBI's resources and, together with our partners on our Joint Terrorism Task Forces, we will continue to work to identify and arrest whoever is responsible for sending these packages," Wray said. "We ask anyone who may have information to contact the FBI. Do not hesitate to call; no piece of information is too small to help us in this investigation."
The FBI said it's possible additional packages were mailed to other locations and advised the public remain vigilant.
The FBI's counterterrorism investigators are leading the investigation and are handling as a domestic terror matter.
The San Diego office of Sen. Kamala Harris, D-California, was also evacuated after "suspicious packages" were found near the building, but they were not addressed to the senator or her office, a spokeswoman tweeted.
New York device investigated
The device sent to the Time Warner Center was a "live explosive device," NYPD Commissioner James O'Neill said at an afternoon news conference, adding that police were also investigating an envelope containing white powder that was found as part of the "original packaging" of the device.
The package was removed from the building late Wednesday morning and was sent to an NYPD facility in the Bronx, a law enforcement official said.
At the news conference, Cuomo disclosed that a device was sent to his Manhattan office and that it was being handled. An NYPD official later told CNN that the device was simply an informational package containing literature.
"There's a number of devices and there's a pattern apparently with them," he said.
The NYPD increased patrols at media locations in the city and other potential areas, a spokesman for the department said. Officials from the ATF and Explosives are at the sites of the multiple packages and were at Soros' Bedford, New York, home on Tuesday, a spokeswoman said. The FBI also is involved in the investigation, the bureau said.
CORRECTION: The name of the Bureau of Alcohol, Tobacco, Firearms and Explosives has been corrected.