CDC warns doctors about childhood illness linked to Covid-19

Doctors are seeing an increase in multisystem inflammatory syndrome in children, or MISC -- a condition that experts say might be linked with the novel coronavirus. CNN's Sanjay Gutpa reports.

Posted: May 15, 2020 6:01 AM
Updated: May 15, 2020 6:01 AM

The US Centers for Disease Control and Prevention issued a health advisory to thousands of doctors across the country Thursday, advising them to be on the lookout for a troubling new syndrome that may be associated with Covid-19 infection.

The syndrome, called multisystem inflammatory syndrome in children (MIS-C), has been seen in children across Europe and in at least 18 states, plus Washington, DC.

Doctors in the UK first alerted other doctors to the syndrome in April. Since then physicians in other countries, including Italy and France, have reported clusters of similar cases.

"Beginning about four or five weeks ago, in Europe they stared to describe a form of what really sounded like toxic shock," said Dr. Jeffrey Burns of Children's Hospital and Harvard Medical School in Boston. Burns has been coordinating a series of regular video chats among doctors around the world comparing notes on pediatric cases of Covid-19.

"There were just a few at first and then more," Burns told CNN.

At first, the cases were believed to be Kawasaki disease, a rare, inflammatory condition that usually involves the major arteries and the heart. But there were too many cases for it to be Kawasaki, and the doctors agreed it was a different inflammatory syndrome. Many, but not all, of the children tested positive either for current Covid-19 infection, or a past infection.

It's only rarely fatal and most children recover, Burns said.

"During March and April, cases of COVID-19 rapidly increased in New York City and New York State. In early May 2020, the New York City Department of Health and Mental Hygiene received reports of children with multisystem inflammatory syndrome," the CDC health advisory reads.

New York Governor Andrew Cuomo said earlier Thursday that the state Department of Health was investigating 110 cases of the syndrome. "It tends to present in children who were exposed to the Covid virus and actually now have the antibodies ... or still test positive for the Covid virus," Cuomo said at a news conference in Albany.

The CDC said it was still gathering information about the cases.

"There is limited information currently available about risk factors, pathogenesis, clinical course, and treatment for MIS-C. CDC is requesting healthcare providers report suspected cases to public health authorities to better characterize this newly recognized condition in the pediatric population."

The advisory provides a case definition to guide doctors:

  • An individual aged under 21 years presenting with fever, laboratory evidence of inflammation, and evidence of clinically severe illness requiring hospitalization, with multisystem (more than 2) organ involvement (heart, kidney, renal, respiratory, blood, gastrointestinal, dermatologic or neurological); AND
  • No alternative plausible diagnoses; AND
  • Positive for current or recent SARS-CoV-2 infection by RT-PCR, serology, or antigen test; or COVID-19 exposure within the 4 weeks prior to the onset of symptoms
  • Fever above 38.0°C (100.4F) for 24 hours or more
  • Abnormal blood tests including: an elevated C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, procalcitonin, d-dimer, ferritin, lactic acid dehydrogenase (LDH), or interleukin 6 (IL-6), elevated neutrophils, reduced lymphocytes and low albumin
  • Some individuals may fulfill full or partial criteria for Kawasaki disease but should be reported if they meet the case definition for MIS-C
  • Consider MIS-C in any pediatric death with evidence of SARS-CoV-2 infection

Indiana Coronavirus Cases

Data is updated nightly.

Confirmed Cases: 47432

Reported Deaths: 2687
CountyConfirmedDeaths
Marion11546683
Lake5104242
Elkhart321144
Allen2737129
St. Joseph190866
Cass16389
Hamilton1538100
Hendricks1390100
Johnson1256118
Porter72037
Tippecanoe6948
Madison65564
Clark64044
Bartholomew58244
Howard56557
LaPorte56326
Kosciusko5354
Vanderburgh5026
Marshall4823
Jackson4693
Noble46928
LaGrange4677
Hancock44035
Boone43743
Delaware43150
Shelby42325
Floyd37144
Morgan32731
Montgomery29320
Grant29126
Clinton2882
Monroe27628
Dubois2666
White26010
Henry25815
Decatur24932
Lawrence24225
Vigo2318
Dearborn22823
Harrison21222
Warrick21229
Greene18532
Miami1822
Jennings17411
Putnam1688
DeKalb1604
Scott1607
Daviess14216
Orange13623
Wayne1366
Steuben1282
Perry1279
Franklin1248
Ripley1157
Jasper1142
Wabash1122
Carroll1102
Fayette987
Newton9810
Starke923
Whitley905
Randolph784
Huntington742
Jefferson722
Wells711
Fulton691
Jay680
Washington681
Gibson672
Knox640
Pulaski641
Clay604
Rush563
Adams501
Benton480
Owen471
Sullivan441
Brown381
Posey380
Blackford372
Spencer371
Crawford300
Fountain302
Tipton301
Switzerland260
Martin220
Parke220
Ohio140
Vermillion140
Warren141
Union130
Pike100
Unassigned0193

Ohio Coronavirus Cases

Data is updated nightly.

Confirmed Cases: 56183

Reported Deaths: 2907
CountyConfirmedDeaths
Franklin10023420
Cuyahoga7571372
Hamilton5770197
Marion273038
Lucas2700302
Pickaway218841
Summit2110206
Montgomery193126
Mahoning1818231
Butler154744
Columbiana129560
Stark1091112
Lorain99767
Trumbull92565
Warren82321
Clark7659
Delaware55315
Belmont54422
Fairfield54316
Tuscarawas54110
Medina50832
Lake49218
Licking46612
Miami45531
Portage43258
Ashtabula43144
Wood41251
Geauga40042
Clermont3946
Wayne36051
Richland3325
Allen30840
Mercer2808
Greene2489
Darke24625
Erie23622
Holmes2263
Huron2112
Madison1938
Ottawa14323
Crawford1355
Washington13120
Putnam12715
Sandusky12714
Hardin12012
Ross1183
Morrow1161
Auglaize1064
Coshocton942
Monroe8817
Jefferson872
Union821
Muskingum811
Hancock781
Hocking788
Preble731
Williams692
Clinton680
Guernsey683
Lawrence680
Shelby654
Fulton610
Ashland581
Carroll583
Logan581
Wyandot586
Brown561
Defiance503
Athens491
Knox481
Fayette460
Highland441
Champaign391
Scioto380
Van Wert340
Seneca332
Perry321
Henry290
Adams231
Paulding230
Pike230
Jackson220
Vinton222
Gallia161
Harrison121
Meigs120
Morgan110
Noble110
Unassigned00
Fort Wayne
Few Clouds
70° wxIcon
Hi: 92° Lo: 68°
Feels Like: 70°
Angola
66° wxIcon
Hi: 90° Lo: 68°
Feels Like: 66°
Huntington
Broken Clouds
67° wxIcon
Hi: 90° Lo: 68°
Feels Like: 67°
Decatur
Clear
64° wxIcon
Hi: 92° Lo: 69°
Feels Like: 64°
Van Wert
Clear
64° wxIcon
Hi: 92° Lo: 68°
Feels Like: 64°
More Heat & Humidity Sunday
WFFT Radar
WFFT Temperatures
WFFT National

Community Events