Expect more cases of strange coronavirus syndrome in kids, doctors warn

The CDC is warning doctors to look out a mysterious illness in children that could be linked to the coronavirus. CNN's Brianna Keilar speaks to a doctor about the symptoms and how to spot any red flags.

Posted: May 14, 2020 3:21 PM
Updated: May 14, 2020 3:21 PM

Parents, hospitals and clinics should expect to see more cases of a mystifying condition that seems to be affecting children after a bout with Covid-19, doctors said Wednesday.

The condition, called multisystem inflammatory syndrome in children, appears to be a post-viral syndrome, said Dr. Jeffrey Burns, a critical care specialist at Boston Children's Hospital who has been coordinating a global group of doctors who compare notes on the condition.

Doctors are investigating cases in at least 150 children, most of them in New York. But a CNN survey finds hospitals and clinics in at least 18 states and Washington, DC are checking into suspected cases.

"This multisystem inflammatory syndrome is not directly caused by the virus," Burns told CNN. "The leading hypothesis is that it is due to the immune response of the patient."

Symptoms include persistent fever, inflammation and poor function in organs such as the kidneys or heart. Children may also show evidence of blood vessel inflammation, such as red eyes, a bright red tongue and cracked lips, said Dr. Moshe Arditi, a pediatric infectious diseases expert at Cedars-Sinai Medical Center in Los Angeles.

British doctors first sounded the alert about the syndrome last month. The Royal College of Paediatrics said Thursday that between 75 and 100 children in Britain had been affected. Italian doctors have also reported the syndrome.

Dr. Ngozi Ezike, director of the Illinois Department of Public Health, said it's a complicated disorder.

"It's a spectrum of disorders, and so in some cases you'll have the individual have coronary artery involvement. Sometimes they don't," Ezike told a news conference.

A delayed response to infection

Not all of the affected children have tested positive for the coronavirus, but reports from Europe and from several cities in the United States show a link.

"There seems to be delayed responses to Covid infections in these kids," Arditi said.

Burns believes more cases will turn up as Covid-19 affects more people. It's a rare condition, but rare consequences of viral infections are seen more often when millions of people are infected.

"We can expect that each of the epicenters will see clusters of these emerging roughly four to six weeks later," Burns told CNN.

"It makes sense that it emerged in New York first because New York had the largest and most severe outbreak (of Covid-19), followed by New Jersey and, unfortunately, Boston."

Most children are not seriously affected by the syndrome, Burns said. Most don't even need treatment in the intensive care unit, he said, although a very few have died. "We do have proven treatments that we can use and are using," he said. They include blood thinners and immune modulators.

The Centers for Disease Control and Prevention is preparing a Health Alert Network notification to send to doctors across the country, a CDC spokesman said. Burns said the World Health Organization is also working to define the syndrome and alert doctors so they will know what to look for and how to treat it.

"This new entity has some similarities to Kawasaki disease," Arditi told CNN. "But there are a lot more features that are consistent with toxic shock syndrome, such as multi-organ system involvement and severe abdominal involvement with diarrhea," he added.

It will be important to study, because the response could help explain why children are so much less likely to be severely affected by Covid-19 than adults are, said Burns.

"Understanding the child's immune response could be a key to vaccine development and could also be a key to therapy for adults to understand why children are able to fight (Covid-19) off so well," Burns said.

Doctors find suspected cases in 17 states

CNN has contacted departments of health, hospitals and state officials around the country to get a sense of how many children are affected, and where.

Some state health departments told CNN that they are waiting for the CDC alert. "We are working with the CDC on a case definition and are looking into possible cases, but won't have more until the CDC finalizes its definition," a spokesman for the Minnesota Department of Health said.

"We don't believe this syndrome is very common, but several cases have been reported elsewhere in association with Covid-19," said Dr. Paul Cieslak, medical director for infectious diseases and immunizations at the Oregon Health Authority Public Health Division. "This syndrome appears to be an uncommon but serious complication of Covid-19 in children."

Paul Mounds, chief of staff for the Connecticut governor's office, said the syndrome would be trackable illness in the state. The Department of Public Health "sent this out to all the Connecticut pediatric health systems to make sure that they are reporting if these cases are occurring in their facilities, so we can be able to track it and handle it accordingly," Mounds said Wednesday.

States reporting cases include:

  • California
  • Delaware
  • Illinois
  • Kentucky
  • Louisiana
  • Massachusetts
  • Michigan
  • Minnesota
  • Mississippi
  • Missouri
  • New Jersey
  • New York
  • Ohio
  • Oregon
  • Pennsylvania
  • Tennessee
  • Utah
  • Washington

Indiana Coronavirus Cases

Data is updated nightly.

Confirmed Cases: 48201

Reported Deaths: 2693
CountyConfirmedDeaths
Marion11624683
Lake5146242
Elkhart328546
Allen2762129
St. Joseph194366
Cass16389
Hamilton1552101
Hendricks1403100
Johnson1278118
Porter72837
Tippecanoe7158
Madison65864
Clark65144
Bartholomew58544
Howard57557
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Kosciusko5464
Vanderburgh5226
Marshall4924
Noble47828
Jackson4703
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Hancock44835
Boone44243
Delaware44250
Shelby42525
Floyd37944
Morgan32931
Grant29426
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Blackford372
Crawford320
Tipton321
Fountain312
Switzerland270
Parke230
Martin220
Ohio170
Vermillion140
Warren141
Union130
Pike110

Ohio Coronavirus Cases

Data is updated nightly.

Confirmed Cases: 57150

Reported Deaths: 2911
CountyConfirmedDeaths
Franklin10271422
Cuyahoga7724373
Hamilton5924197
Marion273238
Lucas2723302
Pickaway219141
Summit2131206
Montgomery198126
Mahoning1825232
Butler157644
Columbiana130360
Stark1107112
Lorain102167
Trumbull93965
Warren83921
Clark7659
Delaware56815
Fairfield55916
Tuscarawas55210
Belmont54622
Medina51632
Lake49718
Licking47712
Miami46331
Portage44058
Ashtabula43344
Wood42151
Geauga40542
Clermont4006
Wayne36251
Richland3375
Allen31540
Mercer2818
Greene2519
Darke24825
Erie24222
Holmes2313
Huron2152
Madison1958
Ottawa14323
Crawford1355
Sandusky13414
Washington13220
Putnam12815
Ross1243
Hardin12312
Morrow1161
Auglaize1064
Coshocton972
Monroe8917
Jefferson872
Union851
Muskingum831
Hancock781
Hocking788
Preble731
Guernsey703
Lawrence700
Williams702
Clinton680
Shelby684
Logan621
Fulton610
Ashland591
Carroll593
Wyandot586
Athens561
Brown561
Knox511
Defiance503
Fayette460
Highland451
Champaign401
Scioto380
Perry341
Van Wert340
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Jackson230
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Vinton222
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Noble110
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