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Certain antibiotics may cause aortic aneurysm, FDA warns

The US Food and Drug Administration ...

Posted: Dec 21, 2018 11:04 AM
Updated: Dec 21, 2018 11:04 AM

The US Food and Drug Administration warned on Thursday that the benefits of fluoroquinolone antibiotics do not outweigh the risks -- which include aortic aneurysm -- for certain patients, according to the latest research. The research is based on reports of patient problems and on studies published between 2015 and 2018.

Fluoroquinolone antibiotics are often used to treat serious respiratory infections, pneumonia, urinary tract infection, and even plague and exposure to anthrax. They include drugs sold under the names ciprofloxacin (Cipro), gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), norfloxacin (Noroxin) and ofloxacin (Floxin).

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Patients take them orally or through injection.

The drugs may cause aortic aneurysm, a bulge in an artery that can grow and burst, causing dangerous or fatal bleeding.

Patients most at risk for an aortic aneurysm after taking these antibiotics are the elderly, those with high blood pressure, people who have a history of blockages of the aorta or other blood vessels, and those who have genetic conditions like Marfan syndrome or Ehlers-Danlos syndrome.

"Although the risk of aortic aneurysm or dissection is low, we've observed that patients are twice as likely to experience an aortic aneurysm or dissection when prescribed a fluoroquinolone drug," FDA Commissioner Dr. Scott Gottlieb said in a statement. "For patients who have an aortic aneurysm or are known to be at risk of an aortic aneurysm, we do not believe the benefits outweigh this risk, and alternative treatment should be considered."

For patients who don't fall into these risk categories, fluoroquinolones may still be a good option. They have been helping patients with bacterial infections for more than 30 years.

The FDA is requiring that a warning about these risks be added to prescribing information and to patient medication guides.

In July, the agency sent a notice that these drugs may significantly decrease blood sugar and negatively impact mental health. In 2016, the FDA said that the drugs may have a disabling side effect on muscles, nerves, joints and the central nervous system and should be restricted for use in some simpler infections.

The FDA said it will continue to monitor for any new safety concerns associated with the antibiotics. "The FDA remains committed to keeping the risk information about these products current and comprehensive and will continue to update the public," Gottleib said.

If you are in one of these at risk categories and are taking one of these antibiotics, experts recommend talking to your doctor about it but continuing to take the medication.

Indiana Coronavirus Cases

Data is updated nightly.

Cases: 749097

Reported Deaths: 13745
CountyCasesDeaths
Marion1030271775
Lake554211006
Allen41613691
St. Joseph36933564
Hamilton36505416
Elkhart29347459
Tippecanoe22849225
Vanderburgh22540400
Porter19313325
Johnson18386387
Hendricks17583317
Clark13190193
Madison13111344
Vigo12602253
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Monroe12152175
Delaware10947197
Howard10250225
Kosciusko9609119
Hancock8541144
Bartholomew8158157
Warrick7854156
Floyd7763180
Grant7227179
Wayne7154201
Boone6911103
Morgan6735141
Dubois6211118
Marshall6205116
Cass5989108
Henry5893108
Dearborn588878
Noble579786
Jackson508374
Shelby500697
Lawrence4727121
Gibson444093
Harrison440473
Clinton439855
DeKalb438585
Montgomery433890
Whitley405642
Huntington402181
Steuben398659
Miami392568
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Knox375690
Putnam371860
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Switzerland8098
Union72810
Ohio57811
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Ohio Coronavirus Cases

Data is updated nightly.

Cases: 1107047

Reported Deaths: 20091
CountyCasesDeaths
Franklin1284921459
Cuyahoga1155972204
Hamilton812991245
Montgomery524821040
Summit48339999
Lucas43303817
Butler38901603
Stark33286929
Lorain25641502
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Mahoning22330601
Lake21135385
Clermont20097252
Delaware18817135
Licking16645222
Fairfield16561204
Trumbull16522479
Medina15593270
Greene15252246
Clark14219306
Wood13280197
Portage13226214
Allen11905239
Richland11598211
Miami10835223
Wayne9116222
Columbiana9020230
Muskingum8889135
Pickaway8649122
Marion8635138
Tuscarawas8633247
Erie8052164
Ashtabula7137179
Hancock6996131
Ross6933161
Geauga6832150
Scioto6528104
Belmont6149174
Union583849
Lawrence5722102
Jefferson5669158
Huron5539122
Sandusky5436125
Darke5415129
Seneca5343126
Washington5308109
Athens523360
Auglaize501587
Mercer487385
Shelby476195
Knox4567112
Madison443765
Ashland435197
Putnam4333103
Fulton431871
Defiance431798
Crawford4033110
Brown401961
Logan387277
Preble3847103
Clinton378466
Ottawa372681
Highland359265
Williams347578
Champaign343658
Guernsey324153
Jackson317354
Perry297150
Morrow291340
Fayette285450
Hardin274865
Henry273267
Holmes2698101
Coshocton268359
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Adams242856
Pike242735
Gallia240450
Wyandot234556
Hocking220162
Carroll196748
Paulding176342
Meigs148240
Monroe136144
Noble135839
Harrison113638
Morgan109624
Vinton85417
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